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大豆異黃酮納米粉體的反溶劑法制備及表征
發(fā)布時間：2019/11/4 15:57:25 瀏覽次數(shù)：752
大豆異黃酮納米粉體的反溶劑法制備及表征
Preparation and Characterization of Soy Isoflavone Nanoparticles by Antisolvent Precipitation Method
DOI：
中文關鍵詞: 大豆異黃酮 微細粉體 反溶劑 表征 粒徑
英文關鍵詞: soy isoflavone powder anti-solvent characterization particle size
以二甲基亞砜作為溶劑，丙酮為反溶劑制備大豆異黃酮納米粉體。通過正交試驗設計法，以大豆異黃酮粒徑為指標，對各個影響因素和水平進行研究，得到最佳的試驗條件。結果：大豆異黃酮的納米粒徑與溶液體積比、勻漿器轉速、溶液濃度呈反比，與反應時間呈正比。大豆異黃酮的最佳試驗條件為：溶液質量濃度300 mg/mL，轉速1 200 r/min，溶劑與反溶劑的體積比1∶6，反應時間3 min。在該條件下得到的納米大豆異黃酮粒徑為98 nm。通過掃描電鏡（SEM）觀測粒子外觀，并用粉體堆密度方法統(tǒng)計。通過紅外光譜（FT-IR）、差熱掃描（DSC）等方法對制備的粉體進行物理化學性質表征。結果表明：制備前、后大豆異黃酮的粉體化學性質沒有發(fā)生改變，納米大豆異黃酮顆粒分布均勻，粒徑顯著減小。
Taking dimethyl sulfoxide as solvent， soy isoflavone powder was prepared by acetone as the anti-solvent. Orthogonal experimental design method was used to in spect the major factors affecting the size and morphology of soy isoflavone powder. Results show that the particle size has a negative relationship with volume ratio， rotor speed and concentration， and has a positive relationship with reaction time. Experiment indicates that the measured powder particle size reaches 98 nm when the concentration is 300 mg/mL； rotor speed is 1 200 r/min； volume ratio is 1 ∶ 6 and reaction time is 3 min. Isoflavone and nano-isoflavone power were evaluated by using scanning electron microscope （SEM）， infrared spectroscopy （FT-IR）， differential scanning calorimetry （DSC） and statistics of powder heap density. Results showed that the chemical properties of isoflavones did not change after preparation. Nano-isoflavone particles were distributed evenly and the particle size decreased significantly.
